Immunohistochemical Examination of P-cadherin in Bullous and Acantholytic Skin Diseases

Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases.

Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cell...

New Observations in Autoimmune Bullous Skin Diseases

Bullous Skin Diseases: Classical Types of Autoimmune Diseases

The prototypic bullous skin diseases, pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, are characterized by the blister formation in the skin and/or oral mucosa in combination with circulating and deposited autoantibodies reactive with (hemi)desmosomes. Koch's postulates, adapted for autoimmune diseases, were applied on these skin diseases. It appears that all adapted Koch's pos...

Evaluation of Diagnostic Agreement between Teledermatology and Clinical Examination of Skin Diseases

Background: Telemedicine provides a tele-communication between physician and patient in remote areas for transferring patient information for the purpose of diagnostic and therapeutic services. Teledermatology is a kind of approach for dermatologists that uses high resolution images for diagnosis. In this study we evaluated the agreement between direct (patient-physician) and indirect (telemedi...

Immunofluorescence Pattern of Autoimmune Bullous Diseases in Iranian Patients

Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detect...